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Cutaneous T-cell lymphoma

This kind of lymphoma first affects the skin and afterward spreads to different parts of the body. The disease’s signs are irritated dim patches on the skin that progressively transform into mushroom shaped tumors.

Causes

In this kind of cancer, the white blood cells are responsible for the disease. The T-lymphocytes (T-assistant cells) create in a wild way and invade into the epidermal layer of the skin, and cause lesions mostly situated in the storage compartment. After some time the lesions transform into tangible plaques with characterized edges and after that into mushroom shaped tumors. At last, the tumor progresses into the lymph nodes and afterward spreads to different parts of the body. The inward organs are affected in 20-30% of the patients who have this disease.

Diagnosis

A specific type of the cutaneous T-cell lymphoma is the Sézary syndrome. Signs of this disease are: a general redness of the skin, small rough tumors, and the skin is atrophic. At physical examination doctors see that the lymph nodes have swollen and discover an increased number of censure lymphocytes.

The disease affects mostly men than ladies, at 55 years old or 60; every year the new cases discovered in US are more than 500 and there are registered 100-200 deaths. The cutaneous T-cell lymphoma is considered to be an uncommon friendship, in US, the yearly frequency being of around .29 cases for every 100,000 persons.

Scientist first suspected that pesticides and chemicals caused the disease, yet subsequent to performing researches they trust that a virus leads to cutaneous T-cell lymphoma. This hypothesis is still not 100% affirmed.

Treatment

For the most part patients go to the doctor because they have an irritated red skin zone that bothers them for quite a while. In the event that the disease has officially spread outside the skin, the patient may feel its lymph nodes swollen.

Usually, the bothersome skin patches can be easily mistaken for other skin diseases, similar to skin inflammation, psoriasis, and contact dermatitis. Doctors prescribe a corticosteroid treatment and in some cases the skin lesions respond positively to it, so the patient carries this disease a couple of years more until the genuine friendship is discovered; then it is past the point where it is possible to treat it.

On the off chance that a doctor is inspired to perform a biopsy of the affected territory he may diagnose the disease prior and treatment could be quickly instituted. At the point when studying the tissue there can be seen strange cells, and by performing a Southern smudge analysis there will be observed changes of the quality that encodes the T-cell receptors. Biopsy is the most precise method for diagnosing cutaneous T-cell lymphoma that is the reason all doctors must request it when suspecting such a disease.

Symptoms

A specific type of the cutaneous T-cell lymphoma is the Sézary syndrome. Signs of this disease are: a general redness of the skin, small rough tumors, and the skin is atrophic. At physical examination doctors see that the lymph nodes have swollen and discover an increased number of defame lymphocytes.

Cutaneous T-cell lymphoma is not the same thing with adult T-cell leukemia or fringe T-cell lymphomas. These are more aggressive skin affections and require distinctive treatment.

For the most part, patients go to the doctor because they have an irritated red skin zone that bothers them for quite a while. In the event that the disease has officially spread outside the skin, the patient may feel its lymph nodes swollen.

Because mistaken cutaneous T-cell lymphoma with other skin diseases is easily, doctors want to perform a tissue biopsy, implying that they uproot the suspected tissue and examine it in the research center to see if there is cancer present and in what stage of evolvement it is. For staging the disease they use that TNM classification: from T1 to T4-the tumors’ spread on the skin; N0 to N3-the lymph’s contribution nodes; M1 or not M0 if there are metastases present or not. Biopsy is the most precise method for diagnosing cutaneous T-cell lymphoma that is the reason all doctors must request it when suspecting such a disease.

 

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