My Accout | Mobile App
Translate »
Powered by Translate


The Ewing sarcoma quality (EWS) has been involved in pathogenesis of an extensive number of soft tissue sarcomas. Its ordinary functions are not clear as of today, despite the fact that it has been involved in cell signaling and RNA processing. Various chromosomal translocations may result in the EWS quality being unusually fused with different genes. These fusion genes may meddle with the ordinary cell cycle and go about as oncogenes, rendering cells undying and resulting in malignant development. This article is an outline of neoplasms in which the Ewing sarcoma quality plays a pathogenetic part.

So what is the Ewing sarcoma quality?

The Ewing sarcoma quality, also known as EWS, is situated on the long arm of chromosome 22. Its definite capacity in human cells remains vague. It has been suggested that the EWS quality codes for a protein included in RNA transcription and splicing. Other suggested roles incorporate DNA repair, control of lymphocyte development, and inclusion in meiosis and gametogenesis.


By blending the EWS quality with different genes as a result of chromosomal translocations, various fusion genes can be delivered. These genes are not typically seen in human cells. The Ewing sarcoma quality in such a fusion product acts as a strong transcription component, initiating and/or upgrading the transcription of the other quality included. This upgraded or distorted transcription interferes with the ordinary cell cycle. The cells get to be everlasting which clinically results in a tumor.

What tumors has the Ewing sarcoma quality been embroiled in?


The accompanying is the list of tumors in which hereditary translocations including the EWS quality assume an imperative part. The visual cues list possible quality fusion products.

Ewing sarcoma/primitive neuroectodermal tumor (PNET)

  • EWS-FLI1

Desmoplastic small round cell tumor

  • EWS-WT1

Myxoid/round cell liposarcoma


Clear cell sarcoma

  • EWS-ATF1

Myxoid chondrosarcoma



So are every one of these tumors identified with Ewing sarcoma?

No. Every one of the tumors listed above are distinct clinical and obsessive entities. The Ewing sarcoma quality is simply a hereditary mechanism that is included in their pathogenesis. Diagnostic features, as well as anticipated clinical conduct, of the tumors listed above are past the scope of this article.

So what?


Are there any reasonable implications in distinguishing the translocations including the EWS quality in these tumors? The answer is yes. Firstly, since numerous soft tissue tumors can resemble the other alike, distinguishing specific hereditary alterations allows to touch base at the exact diagnosis. Besides, in some instances such a translocation defines the tumor, i.e. the diagnosis must be dependably made by recording the tumor’s hereditary cosmetics.

The utility of the hereditary studies does not, nonetheless, stop here. In numerous instances specific hereditary alterations permit to anticipate clinical conduct and even select focused on treatment agents.

Disclaimer. The substance of this article is not proposed as a substitute for medical guidance. In the event that any of the conditions specified above affects you, or you have questions about the materials presented here, it is best to consult your doctor.