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Ovarian cancer represents around 25% of all female genital tract malignancies. Be that as it may, there are more deaths from this type of cancer every year in the United States than from endometrial cancer and cervical cancer joined. The lifetime risk of creating spontaneous ovarian cancer is around 1.7%. Epithelial ovarian cancer was normal cause 15,520 deaths in 2008. Mean age at diagnosis is 60. There has been a significant change in the five year survival rate for patients with ovarian cancer. This is likely a blend of better tumor debulking surgeries and better chemotherapeutic options.
Most patients with this sort of ovarian cancer don’t have signs or symptoms until disease spreads to the upper belly. 70% of patients present with cutting edge disease. Symptoms for ahead of schedule stage ovarian cancer can incorporate nonspecific pelvic discomfort, urinary recurrence and constipation which are caused by a broadening pelvic mass. With cutting edge disease, patients experience stomach torment, bloating, anorexia, nausea and constipation.
The best tumor marker for ovarian cancer is CA 125. Minor elevations in CA 125 can also be seen in endometriosis, kind tumors, fibroids and in pregnant and postpartum ladies. Also, direct height of CA 125 can be seen in other adnocarcinoma such as breast and endometrial cancer. The sensitivity of CA 125 is 70% to 80% and the specificity is 98.6% to 99.4%. Notwithstanding, in the normal risk populace with low commonness of ovarian cancer, the false positive can be inadmissibly high.
Treatment and diagnosis
The National Cancer Institute recommends screening for ovarian female cancer with known hereditary syndromes associated with this disease and for ladies with strong family history. Routine screening of ladies without family history of ovarian cancer is not prescribed. The known hereditary syndromes incorporate genetic breast and ovarian cancer syndrome associated with BRCA 1, BRCA 2 and Hereditary Nonpolyposis Colorectal Cancer Syndrome (HNPCC). The absolute risk of ovarian cancer in the presence of either BRCA 1 or BRCA 2 change ranges from 16% to 60%. For patients with HNPCC syndrome, the lifetime risk of ovarian cancer is 9% to 12%.
Epithelial cancer accounts for around 90% of ovarian cancers. Basic histologies incorporate serous, mucinous, endometroid, transitiona and clear cell types. Germ cell tumors incorporate dysgerminoma, endodermal sinus tumor, malignant teratomaembryonal carcinoma or essential choriocarcinoma. Stromal tumors incorporate granulose tumor or Sertoli-Leydig tumor.
Upon starting presentation, surgery is used for affirmation and staging the cancer. Stage I disease is limited to one or both ovaries. Stage II involves one or both ovaries with extension to the pelvic viscera. Stage III is associated with implants on the abdominopelvic divider or the serosal surface of the liver or involves small bowel or omentum. Stage IV disease involves distant metastasis. The 5 year survival for stage IA disease and grade 1 or 2 histology is more prominent than 90%. For high risk stage I disease and stage II disease, 5 year survival is 80%. For patients with stage III disease after ideal debulking, 5 year survival is 20% to 30%. This reduces to be less than 10% for stage III patients with suboptimal debulking and stage IV disease.